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Excerpt from Editorial of first issue:

"Open Medicine is a new general medical journal. It will be paperless and available without charge or any other barrier to access online. We will publish peer-reviewed science and analysis as well as clinical articles. We will provide a forum for informed and inclusive debates on medicine and its application. Open Medicine will be independent of any commercial publisher or association ownership - it will be "owned" by all who read and contribute to it - and will take no advertisements from companies selling pharmaceuticals or medical devices. We will rely on voluntarism, donations and ethical advertising. Any revenue will be used to improve our ability to meet the needs of our readers and contributors.

This first edition of Open Medicine offers carefully reviewed and edited articles for discovery and discussion. In the future, it is our intention to make the journal not only open, but also collaborative. As an example, the editors considered the merits of publishing peer reviews along with accepted papers, and began reviewing the published evidence on the effectiveness of open peer review. Before reaching consensus, we realized that this is a discussion our readers and contributors should actively participate in. As we developed Open Medicine, we made extensive use of a wiki site and quickly realized how well it captured our combined efforts. We will continue to experiment with its use as an editing tool, and are discussing ways to add a wiki to our public site."